Immunotherapy 101.
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Curex is the largest online allergy & asthma clinic. We specialize in at-home immunotherapy & personalized treatments.

Immunotherapy 101

Curex is the largest online allergy & asthma clinic. We specialize in at-home immunotherapy & personalized treatments.



What is Immunotherapy?

Allergy immunotherapy is the repeated administration of small, medical-grade allergen extracts to individuals with allergies in order to build tolerance and decrease their reactivity to their allergens. The goal is to provide long-term relief from allergy symptoms and improve your quality of life by reducing reactions to allergens in the future.

Each immunotherapy treatment is customized to the individual patient based on your medical history, test results, and lifestyle needs.

What is the goal of allergy immunotherapy?

The goal of allergy immunotherapy is to reduce allergy symptoms, making it easier for you to live free of sneezing, sniffling, and itching. Ultimately, the goal is decreasing the need for allergy medications and enabling people to live healthier, more productive lives.

What is the difference between immunotherapy and other allergy medications?

Allergy medications such as antihistamines (e.g. Benadryl, Zyrtec, Claritin, etc.) and nasal steroids (e.g., Flonase, etc.) offer short-term relief in symptoms by treating the body’s response to the allergic reaction. These medications are convenient and many don’t require a prescription. Their efficacy and side effects vary from patient to patient.

Immunotherapy is a prescription treatment —prescribed and supervised by a U.S. licensed clinician — that aims to train the immune system not to have an allergic reaction in the first place. Thus, immunotherapy improves your symptoms by treating the source of your allergies and decreases your need for ongoing medications.  This treatment has been used by physicians in the U.S. and Europe for more than 100 years and has helped millions of patients.

How does the immunotherapy program work?

To start, an experienced clinician evaluates your medical history and symptoms. Most patients are recommended to take an allergy test to help establish a diagnosis.

Once the diagnosis is established, your clinician may recommend an immunotherapy treatment, if appropriate. Every treatment is tailored to the patient's specific allergies. Then a specialized immunotherapy pharmacy fulfills the order by shipping the treatment to your home once every three months.

You begin taking immunotherapy at home daily, under your tongue for about 2 minutes. If you have questions, you can easily connect with your clinician via text, email or zoom.

During immunotherapy, your body is exposed to controlled, medical-grade doses of allergens over time. This trains your immune system not to overreact to the allergen. As a result, you will begin reducing symptoms and the need for medications.

The treatment normally takes at least three years, though many patients begin experiencing noticeable improvements within the first six months.

How much does immunotherapy cost?

At-home immunotherapy is customized by clinicians to your allergies. You receive your treatment delivered to your door quarterly. Plus, you receive ongoing care & support from your dedicated clinician, including 1-1 telehealth visits and prescriptions as needed. 

Curex offers two pricing plans:

Monthly Plan - $95 billed every month.

Annual Plan ($75/month or >20% off) - $900 billed annually. Most popular choice as it saves you $240 per year.

Treatments are shipped in 3 month installments in all plans. Cancellations are accepted prior to the next refill being shipped by the pharmacy (so you can get a partial refund on a prepayment plan).

What allergies does immunotherapy treat?

Immunotherapy has a long history of successfully treating allergic rhinitis and conjunctivitis caused by environmental allergies. It can also improve allergy-induced asthma, eczema, and a variety of other allergy-related conditions. Commonly treated allergies include pollen, dust, weeds, pets, and mold.

Allergies to food, bee and insect venom, medicine, and chemicals can also be treated with immunotherapy, but normally require in-person observation by a clinician.

Is immunotherapy safe?

Immunotherapy has been practiced for over 100 years and all forms are considered extremely safe. However, there is always the possibility of having a severe allergic reaction called anaphylaxis that can be life-threatening. Although this is very rare, these reactions are most commonly observed with allergy shots. Thus, it is recommended that you are observed in the doctor’s office for 20-30 minutes after your shot and have an epinephrine device (i.e EpiPen) with you in the event that you have a reaction after you leave the office.  

Sublingual immunotherapy is considered much safer and there have been very few reports of anaphylaxis in the medical community. The incidence of severe allergic reactions to sublingual immunotherapy has been reported at 1 per 100 million doses or 1 in 526,000 treatment years.  As a result, it is considered safe for home use. Despite its proven safety, Curex clinicians still recommend having an epinephrine device handy when using sublingual immunotherapy.

I have asthma. Can immunotherapy help me?

Yes, when added to an asthma treatment regimen, sublingual immunotherapy has been shown to lead to a significant reduction in the inhaled corticosteroid dose required to maintain asthma control. Furthermore, in patients with suboptimally controlled asthma, when added to inhaled corticosteroids,  it has been shown to increase the time to exacerbation when reducing the inhaled corticosteroid dose.

I have eczema / atopic dermatitis. Can immunotherapy help me?

Sublingual immunotherapy has been shown to improve the extent and severity of atopic dermatitis as well as the skin lesion area while decreasing the medications needed to treat it.

What types of immunotherapy are available?

Sublingual: daily allergy tablets or drops taken under the tongue at home.

Subcutaneous: weekly allergy injections (shots) given at a local doctor’s office.

Sublingual tablets cover one allergy at a time. Options that are currently FDA-approved treat dust mite (Odactra), ragweed (Ragwitek), Timothy grass (Grastek) and a 5-Grass Mixture (Oralair). The first dose is required to be done in-person with an experienced allergy provider.

Sublingual drops can treat several allergens at a time. Experienced clinicians customize compounds to each individual patient’s allergenic profile and needs, using established dosing and treatment protocol. Such drops treat a wide array of inhalant allergens, including trees, grasses, weeds, dust, pets, and molds. Immunotherapy drops (aka “liquid SLIT”) is an off-label administration of the same FDA-approved allergenic extracts used in allergy shots.

Subcutaneous immunotherapy (allergy shots) treat several allergens simultaneously, as well. Allergy shots require in-person observation due to a higher risk of a severe allergic reaction.  If this is the right treatment modality for you, we will try to connect you with an experienced allergist in your area.

Is sublingual immunotherapy as effective as shots?

Yes, sublingual and subcutaneous immunotherapy are both proven to be effective ways to target the source of allergies. Studies have shown the sublingual method has a lower risk for anaphylaxis, allowing you to take it at home or while traveling. As a result, sublingual treatment is more convenient and generally more affordable.

Why haven't I heard of sublingual immunotherapy before?

Sublingual immunotherapy is prevalent in many countries. For example, nearly 90% of immunotherapy treatments in France are administered sublingually. In the U.S., sublingual immunotherapy has existed for almost 40 years.  It has historically had low adoption due to limited insurance coverage and no clear FDA approval.  This changed recently when the FDA cleared several sublingual tablets after reviewing clinical data on efficacy and safety.  

In addition, most allergy clinics are highly experienced with in-person care required for allergy shots, but are less well suited to provide telemedicine supervision appropriate for sublingual immunotherapy.

What is Curex?

Curex is an innovative telehealth platform that unites allergy clinicians, allergy-testing labs and leading pharmacies for your convenience. Founded during the COVID pandemic, Curex provides trusted allergy care online for over 20,000 customers across every state. Our goal is to expand access to life changing allergy immunotherapy for the 50 million Americans who need it.