What Allergy Shots Are Available? Complete Allergen Directory
Over 100 environmental allergens have FDA-licensed extracts available in the United States, supplied by three manufacturers: ALK-Abello, Stallergenes Greer, and Jubilant HollisterStier. Categories include grasses, trees, weeds, dust mites, animal danders, molds, and Hymenoptera venoms. Key restriction: proteolytic allergens cannot be mixed with pollen in the same vial. Food allergen SCIT is not available. Curex's At-Home Allergy Shot Kit draws on the same FDA-licensed extract pool — a personalized multi-allergen serum sterile-compounded to USP <797> and self-administered weekly at home for $129/month.
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Over 100 environmental allergens are available as allergy shot extracts in the US, including grass and tree pollens, dust mites, pet danders, mold spores, and insect venoms. Food allergen SCIT is not available. Three manufacturers supply the entire US market.
The Complete US Allergy Shot Product Catalog: What's Available
The United States has a robust market for allergen immunotherapy extracts, with over 100 environmental allergens available as FDA-licensed injectable preparations. The entire supply comes from three manufacturers: ALK-Abello (headquartered in Denmark with US operations), Stallergenes Greer (France/US), and Jubilant HollisterStier (US). Your allergist orders individual extracts from these manufacturers and compounds a patient-specific multi-allergen vial tailored to your sensitization profile.
Before you can determine which extracts go into your vial, you need to know which allergens trigger your immune response — Curex at-home allergy testing identifies your IgE sensitization profile across 40+ allergens, giving your allergist the blueprint to select the right extract combination.
A critical distinction in product availability: only about 19 allergens have FDA-standardized extracts with validated potency in BAU (Bioequivalent Allergy Units) or AU (Allergy Units). The remaining 100+ allergens use non-standardized PNU or w/v potency designations. Standardized extracts provide more reliable dose comparisons, while non-standardized extracts rely on manufacturer-specific calibration. Curex sources from the same FDA-licensed manufacturer catalog to compound personalized at-home SCIT serums: one weekly subcutaneous shot at home for $129/month, sterile-compounded to USP <797> and prescribed by a board-certified allergist.
Three manufacturers control the entire US allergen extract market — and mixing restrictions (proteolytic allergens cannot share a vial with pollens) are why your allergist may use two vials instead of one.
How Custom Multi-Allergen Vials Are Assembled
Your allergy shot vial is not an off-the-shelf product — it is a custom pharmaceutical formulation assembled specifically for your sensitization pattern. Understanding how vials are built helps explain why mixing restrictions matter.
Allergen Category Selection
After skin prick testing or specific IgE blood testing, your allergist identifies which allergens produced positive results above the clinical threshold. Only sensitized allergens are included in your extract — treating to non-reactive allergens adds cost without benefit and may increase reaction risk.
Proteolytic Enzyme Separation
Cockroach, house dust mite, and certain mold extracts contain proteolytic enzymes that degrade protein allergens from other species when combined in the same vial. To prevent this degradation — which can significantly reduce pollen extract potency within weeks — allergists separate allergens into two vials: one for protease-active allergens and one for pollens. Both vials are administered at each visit.
Potency Calibration
Standardized allergens (cat, dust mite, major grasses, ragweed, venoms) are measured in BAU or AU. Non-standardized allergens (most tree pollens, mold spores, other danders) are measured in PNU or w/v ratios. Your allergist calibrates the maintenance dose for each allergen based on published target dose ranges and your individual sensitivity during build-up.
Vial Preparation and Labeling
Vials are prepared in-office or at a compounding pharmacy licensed for allergen extract preparation. Each vial is labeled with your name, allergen contents, concentration series (most dilute to maintenance concentrate), and expiration date. Vials must be stored at 2–8°C to maintain potency. Glycerinated concentrates last approximately one year; dilute aqueous vials degrade faster and are typically replaced more frequently.
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See if at-home shots are right for youFrequently asked questions
Can allergy shots treat tree pollen allergies?
Yes — a wide range of tree pollen extracts are available for allergy shots. Available tree pollens in the US include oak, birch, cedar, maple, elm, ash, hickory, sycamore, cottonwood, mulberry, olive, and many others from the major manufacturer catalogs. Note that tree pollen extracts are non-standardized (no BAU or AU equivalent) — they use PNU or w/v potency designations, meaning potency calibration relies on the manufacturer's own reference standards. Regional relevance matters significantly: birch is the dominant sensitizing tree pollen in northern states, while mountain cedar (Juniperus ashei) is critical in Texas and Oklahoma. Your allergist will include tree pollen extracts for species prevalent in your geographic area that showed positive sensitization on your allergy test.
Are allergy shots available for mold allergies?
Yes, but with caveats. The main clinically relevant mold allergens with available SCIT extracts include Alternaria alternata, Aspergillus species, Cladosporium herbarum, Penicillium notatum, and Helminthosporium. All mold extracts are non-standardized. A significant limitation is the proteolytic enzyme problem: mold extracts contain enzymes that can degrade pollen proteins, so mold cannot be mixed with pollens in the same vial. Evidence for mold SCIT efficacy is also more limited than for pollens or dust mites — the strongest mold data exists for Alternaria. Many allergists are more conservative with mold immunotherapy and may require higher symptom burden before initiating treatment. For outdoor mold-dominant allergies, environmental control measures are often pursued alongside or instead of immunotherapy.
Can you get allergy shots for dog or cat allergies?
Yes — both cat and dog dander extracts are available for allergy shots. Cat extract (Fel d 1 protein from sebaceous gland secretions) is one of the FDA-standardized allergens, meaning its potency is validated in standardized units (BAU). Dog extract is non-standardized and uses w/v or PNU designations. Clinical evidence for cat allergy SCIT is well-established; evidence for dog allergy immunotherapy is moderately strong. A practical consideration: patients with cat or dog allergies who cannot avoid the animal (because they own pets) often see the most benefit from immunotherapy, as environmental avoidance is difficult. Patients who have already reduced cat or dog exposure and whose symptoms are well-controlled may show less improvement with shots because their allergen exposure is already low.
Why can't cockroach and mold extracts be mixed with pollen in the same vial?
Cockroach, dust mite, and certain mold extracts contain proteolytic (protein-degrading) enzymes — particularly serine and cysteine proteases — that actively break down the protein structure of pollen allergens over days to weeks when combined in the same vial. Research by Grier et al. (Ann Allergy Asthma Immunol 2007) documented measurable pollen allergen degradation in mixed vials containing proteolytic extracts. The degradation reduces or eliminates the pollen component's immunological potency, meaning the patient receives an effectively under-dosed pollen treatment. To avoid this, allergists prepare two separate vials and administer both at each visit: one vial containing the proteolytic allergens (mold, cockroach, dust mite) and one containing the pollens. This two-vial approach adds a second injection at each visit but preserves the potency of all components.
What venom allergy shots are available?
Venom immunotherapy extracts are available for the five stinging insects responsible for the majority of venom anaphylaxis in the United States: honeybee (Apis mellifera), yellow jacket (Vespula species), white-faced hornet (Dolichovespula maculata), yellow hornet (Dolichovespula arenaria), and paper wasp (Polistes species). All Hymenoptera venom extracts are FDA-standardized, with potency measured in micrograms of protein. Fire ant whole-body extract (not venom extract) is also available for patients in fire ant endemic regions. Venom identification is critical — skin testing or specific IgE testing identifies which venom(s) you react to, as cross-reactivity between yellow jacket and hornet venoms can complicate interpretation. Mixed vespid extract is available for patients who react to multiple vespid species.
Are allergy shots available for latex allergy?
No — latex allergy shots are not currently available in the United States. Latex allergen extracts were previously available but were withdrawn from the US market due to an unacceptable rate of severe allergic reactions during immunotherapy, including multiple fatalities. Natural rubber latex (NRL) extract is considered too dangerous for subcutaneous immunotherapy in clinical practice. The primary management strategies for latex allergy are strict latex avoidance and carrying epinephrine auto-injectors for emergency use. Some research into sublingual or intradermal desensitization protocols for latex has been conducted in Europe but is not available in the US market. If you have a documented latex allergy, inform all healthcare providers before any medical or dental procedure, as latex gloves and medical devices are a common exposure source.
How many allergens can be included in one set of allergy shots?
There is no strict regulatory limit on the number of allergens included in an allergy shot vial, but practical and clinical constraints typically limit most vials to 2–10 allergens. Including too many allergens in a single vial requires diluting each individual allergen to a lower concentration to maintain safe total volume and protein load, potentially reducing the effective dose of each component. Allergists prioritize the allergens that are clinically most relevant — highest sensitization level, greatest geographic prevalence, most symptom-driving — rather than including every positive test result. Many patients receive two vials at each visit (one for proteolytic allergens, one for pollens) to maximize potency of each component. Your allergist's clinical judgment determines which combination of allergens gives you the best balance of efficacy and safety.
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This content is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. Content reviewed by board-certified allergists at Curex.