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Every guide is anchored to peer-reviewed citations (Cox 2011 Practice Parameter, Cochrane meta-analyses, CMS Physician Fee Schedule data) and reviewed by board-certified allergists.
Comprehensive guides answering your most common questions about allergy shot therapy.
What to expect after each injection — local reactions, safety timelines, and emergency care.
How allergy shots work, efficacy data, and comparisons with sublingual immunotherapy.
Deep dives into subcutaneous immunotherapy science — mechanisms, outcomes, and research.
Real pricing — CMS-verified CPT codes, 50-state cost data, and 14-carrier insurance coverage.
Browse SCIT treatment guides for 198 specific allergens — pollen, animals, mold, mites, venom.
State and city allergen data, costs, and insurance coverage for every US location.
Allergy shots are one of the most studied immunotherapies in medicine, with over 100 years of clinical evidence. Curex pairs that proven science with modern at-home safeguards, clinical oversight, and pharmacy-grade quality.
“Six months in, my dust mite reactions are gone.”— Verified patient
Throat tightness, difficulty breathing, generalized hives outside the injected arm, or lightheadedness after a shot — call 911 and use your epinephrine auto-injector immediately. Severe reactions are rare (1 in 23.3M injections per AAAAI/ACAAI surveillance), and your epinephrine and emergency plan are confirmed in place before your first at-home dose.
Unlike antihistamines that mask symptoms, allergy shots address the root cause. Tiny doses of your specific allergens, delivered consistently over time, teach your immune system to stop overreacting — inducing regulatory T cells and IgG4 blocking antibodies (Cox 2011 Practice Parameter; Cochrane SMD −0.73).
Stylized — actual immune shifts vary by allergen and individual response per Durham 1999 NEJM long-term follow-up.
A board-certified allergist reviews your profile to pinpoint the exact allergens driving your symptoms.
A personalized immunotherapy serum is compounded for you, matched to your specific allergen profile.
A painless weekly shot, often compared to a mosquito bite, gradually exposes your body to build real tolerance.
Your immune system shifts from IgE-driven overreaction to protective IgG4 responses — the root cause fix.
Clinical data shows benefits can persist for years after treatment ends — true disease modification.
No clinic visits. No waiting rooms. A board-certified allergist designs your serum and ships everything to your door.
Two minutes of questions about your triggers, symptoms, and history.
A licensed physician reviews your case and prescribes a custom immunotherapy serum.
Your personalized serum, syringes, and step-by-step guide arrive at your door — typically within 5 business days.
A painless weekly self-administered dose, usually done in under a minute. Care team support 24/7.
Allergy shots (SCIT) are the most proven allergy treatment in medicine. Curex brings that same treatment home — no weekly clinic visits, no copays, no waiting rooms.
HOPD facility-fee risk anchored to documented cases: $24,400 M Health Fairview (PBS NewsHour 2024); $48,329 Stanford patch testing (KFF Health News). See real EOBs below.
I was skeptical about doing shots myself but the instructions are dead simple and my allergist messages me weekly. Four months in, my dust mite reactions are maybe 15% of what they used to be.
Where would you place your current symptom severity?
Projection based on average ~78% symptom reduction in patients who reach maintenance (Tkacz 2021 MarketScan n=103,207 · Cochrane Calderón 2007 SMD −0.73). Individual results vary.
Every other allergy-shot article quotes vague ranges. We show de-identified explanation-of-benefits documents — what was billed, what insurance paid, what the patient owed.
EOB image redacted
Typical maintenance visit at a Texas allergist — $30 copay. CPT 95117 + 95165 billed.
Representative · PayerPrice BCBS 95117 nat'l avg
EOB image redacted
Hospital outpatient department billed 40-allergen skin testing at $24,400 — 30× the typical fee.
REAL · Kaitlin Johnson · PBS NewsHour 2024
EOB image redacted
119-allergen patch test at Stanford. Anthem accepted the inflated billed amount as in-network.
REAL · Janet Winston · KFF Health News / NPR
Adjust your insurance type, distance to clinic, and time per visit. We model the full 3-year out-of-pocket — visits, copays, travel, and time off — vs Curex flat $129/mo/mo.
Based on real CPT 95115 / 95117 / 95165 billing data, not generic price ranges.
Time at clinic valued at $25/hr opportunity cost (national median wage). Direct medical costs from CMS Physician Fee Schedule + commercial payer data. Travel at $0.21/mi (gas + wear).
Cost model anchored to CMS Physician Fee Schedule (CPT 95115/95117/95165), AAAAI/ACAAI dosing schedules, and federal IRS mileage rates. Time cost uses $25/hr opportunity model (2 hrs/visit including travel).
Clinic-based shots typically run $2,000–$4,000/year in copays and visit fees. Curex delivers the same care at home for far less, with no appointments to miss.
Subcutaneous immunotherapy (SCIT) introduces tiny, gradually-increasing doses of your specific allergens. Over weeks and months, your immune system shifts from IgE-driven overreaction to protective IgG4 antibodies and regulatory T cells (Treg). Cochrane Calderón 2007 meta-analysis of 51 RCTs documented symptom SMD −0.73 and medication SMD −0.57 vs placebo — among the largest effect sizes in allergy medicine.
Your personalized serum, prescribed by a board-certified allergist and shipped directly to your door. No clinic visits. Cancel anytime.
Get Started"Ran a 5K PR this spring with zero pollen meltdown. Shots cleared it all up by year two."
Board-certified allergists. Personalized immunotherapy. One weekly shot. No clinic visits. Starting at $129/mo. Begins with a 2-minute quiz.
Starting at $129/mo/mo · Save 46% on annual · HSA / FSA eligible · Cancel anytime
