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View ResearchExplore the optimal timeframe for donating convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy. This study shows that SARS-CoV-2 IgM, IgG, and virus neutralization responses persist robustly for at least 100 days post-symptom onset, with the best donation window within the first 60 days. These findings help refine donor selection criteria to enhance the efficacy of convalescent plasma therapy.
Optimal Window for Convalescent Plasma Donation
Study reveals the best time to donate convalescent plasma for COVID-19 immunotherapy is within 60 days post-symptom onset.
Persistence of SARS-CoV-2 Antibody Responses
Research shows robust IgM, IgG, and virus neutralization responses persist for at least 100 days post-symptom onset.
Decline of Virus Neutralization Titers After 60 Days
Significant decline in virus neutralization titers suitable for convalescent plasma therapy observed after 60 days post-symptom onset.
Factors Influencing Convalescent Plasma Donor Suitability
Ideal plasma donors are over 30 years old and had severe COVID-19, showing higher and more durable antibody responses.
Predictive Markers for High-Titer Plasma Donation
Anti-S/RBD IgG titers of more than 1350 identified as reliable predictors for high virus neutralization titers in plasma donors.
Impact of Age and Severity on Antibody Response
Younger individuals and those with mild COVID-19 show lower and shorter-lasting antibody responses compared to older, severely affected patients.
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