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View ResearchExplore the morphofunctional analysis of antigen uptake mechanisms following sublingual immunotherapy (SLIT) with beads in mice. This study investigates how different regions of the sublingual mucosa absorb antigens, revealing significant findings in the sublingual caruncles, oral rostral mucosa, and buccal mucosa. The research highlights sex-related differences in antigen uptake, with females showing higher bead accumulation, suggesting potential impacts on the efficacy of SLIT.
Antigen Uptake in Sublingual Immunotherapy
Study reveals key mechanisms of antigen uptake through sublingual mucosa in mice using fluorescent beads.
Gender Differences in Sublingual Immunotherapy
Investigation shows females have higher antigen uptake in sublingual immunotherapy, suggesting sex-specific efficacy.
Age and Antigen Uptake in Immunotherapy
No significant age-related differences found in antigen uptake through sublingual mucosa in mice.
Role of Sublingual Ducts in Immunotherapy
Study identifies sublingual ducts as crucial for local immunity and antigen uptake in sublingual immunotherapy.
Morphological Analysis of Sublingual Mucosa
Detailed SEM and LM analysis reveals antigen uptake sites and mechanisms in the sublingual mucosa of mice.
Implications for Human Sublingual Immunotherapy
Findings suggest sex-specific differences in antigen uptake could influence the effectiveness of sublingual immunotherapy in humans.
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