What’s inside
View ResearchExplore the origins and diversity of pan-isotype human bone marrow plasma cells (BMPCs) in both food-allergic and non-allergic individuals. This study utilizes single-cell RNA sequencing and CITE-seq to chart the transcriptional and clonal heterogeneity of BMPCs, highlighting the unique properties and sources of IgM, IgG, IgA, and pro-allergic IgE antibodies. Findings reveal distinct functional profiles and the bone marrow as a source of pathogenic IgE in peanut allergy.
Origins of Pan-Isotype Bone Marrow Plasma Cells
Study reveals the transcriptional and clonal diversity of human bone marrow plasma cells and their origins.
Functional Profiles of Bone Marrow Plasma Cells
Analysis uncovers distinct functional profiles and somatic hypermutation in bone marrow plasma cells.
Peanut Allergy and Bone Marrow Plasma Cells
Research highlights bone marrow as a source of pathogenic IgE in peanut allergy, with functional relevance in vivo.
Surface CD19 Expression in Plasma Cells
CD19 expression levels correlate with plasma cell longevity and functional profiles in bone marrow.
Antibody Production in Allergic Individuals
Study shows high metabolic demand and ER stress in IgE-producing plasma cells from allergic individuals.
Clonal Analysis of Plasma Cells
Detailed clonal analysis reveals distinct origins and functional characteristics of human bone marrow plasma cells.
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