What’s inside
View ResearchExplore how spatial colocalization of natural killer (NK) and CD8 T cells impacts survival in non-small cell lung cancer (NSCLC) despite MHC class I loss. This study reveals that high densities of NK and CD8 T cells, particularly when colocalized, correlate with improved disease-free and overall survival. The findings suggest potential for combined immunotherapies targeting both NK and CD8 T cells to enhance anti-tumor immunity, even in tumors with MHC-I loss.
NK and CD8 T Cells in NSCLC Survival
Study shows spatial colocalization of NK and CD8 T cells enhances survival despite MHC-I loss in NSCLC.
Spatial Analysis of Immune Cells in Lung Cancer
Research uses multiplex immunofluorescence to analyze immune cell infiltration and MHC-I expression in NSCLC.
NK Cells and Tumor MHC-I Heterogeneity
NK cells colocalize with CD8 T cells in MHC-I+ NSCLC tumors, improving patient outcomes.
Impact of MHC-I Loss on Immune Infiltration
Study reveals MHC-I loss in NSCLC tumors affects NK and CD8 T cell infiltration and activity.
IFNγ+ Lymphocytes in NSCLC Tumor Control
IFNγ+ NK and CD8 T cells cluster in MHC-I+ regions, suggesting coordinated tumor control in NSCLC.
Combining NK and T Cell Immunotherapies
Findings support combined NK and T cell therapies to enhance antitumor immunity in NSCLC with MHC-I loss.
.svg)
.jpg)
.webp)
