Allergy Immunotherapy Researches

CAR-T Breakthrough: AML-Specific Integrin-β2 Identified as Therapy Target

Discover the CAR-T breakthrough targeting AML-specific integrin-β2, identified through structural surfaceomics. This promising approach shows CAR-T cells can eliminate AML cells without harming normal ones, offering a new hope in immunotherapy with minimal toxicity.

Written and prepared by:

Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J. Adams, Michael R. Hoopmann, William C. Temple, Bonell Patiño Escobar, Maryna Gorelik, Christian H. Ihling, Matthew A. Nix, Akul Naik, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D. Leavitt, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine C. Smith, Robert L. Moritz, Sachdeva S. Sidhu, Lan Huang, Arun P. Wiita

What’s inside

View Research

Dive into the study on AML-specific integrin-β2 conformations targeted by CAR-T therapy. Utilizing structural surfaceomics, this research identifies integrin-β2's active form on AML cells, presenting a potential immunotherapy target. Developed CAR-T cells showed efficacy in eliminating AML cells without harming normal hematopoietic cells, suggesting a promising therapeutic approach with minimal toxicity.

Structural Surfaceomics in AML Therapy

Discover AML-specific conformations of integrin-β2 for CAR-T therapy.

CAR-T Cells Targeting Integrin-β2 in AML

Explore how integrin-β2 specific CAR-T cells show efficacy in AML treatment.

Overcoming Challenges in AML Immunotherapy

New approaches to target AML-specific antigens and improve CAR-T cell safety.

Integrin-β2 Conformation in Cancer Therapy

Study reveals active integrin-β2 as a promising target in AML with minimal toxicity.

Preclinical Evaluation of CAR-T Cells for AML

Assessing the safety and efficacy of integrin-β2 targeted CAR-T cells in AML models.

Future of AML Immunotherapy

Insights into using structural surfaceomics for conformation-specific AML targets.

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