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Curex does not treat this allergen







Dr. Chet Tharpe, M.D..
Updated May 3, 2025
One of the most common symptoms of a watermelon allergy is itching or hives. These appear as red, itchy rashes on the skin, typically around the mouth and lips, but they may also spread to other parts of the body.
Swelling, particularly of the face, lips, tongue, and throat, is another symptom of a watermelon allergy. This can cause discomfort and in severe cases, can interfere with breathing and necessitate immediate medical attention.
Some people may experience stomach cramps or upset stomach after eating watermelon. This is due to the body's immune system responding to the perceived threat posed by certain proteins found in the fruit.
Nasal congestion manifests itself with a stuffy or runny nose. This symptom arises as part of the body's immune response to an allergen, in this case, watermelon.
A severe reaction to watermelon can lead to gastrointestinal issues such as vomiting or diarrhea. This is the body's way of trying to eliminate the allergen from its system quickly.
In the most severe cases, watermelon allergies can lead to anaphylaxis, a severe, potentially life-threatening allergic reaction. Symptoms include difficulty breathing, reduced blood pressure, loss of consciousness, and in some cases, death. Anaphylaxis requires immediate medical attention.
Recognize your symptoms?

Recognizing if you have a watermelon allergy involves identifying the common symptoms of food allergies and then establishing contact or consumption of watermelon. The following guide will further explain this.
Identify Common Food Allergy Symptoms
Assess Contact or Consumption of Watermelon
Seek Medical Confirmation
Note that severe allergic reactions can lead to anaphylaxis, a life-threatening medical emergency. Seek immediate medical attention if you experience a rapid pulse, severe difficulty in breathing, or loss of consciousness after consuming watermelon.



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Your first line of defense should be to simply try to avoid consuming watermelon. If you have been diagnosed with a watermelon allergy, it is best to completely eliminate this fruit from your diet. Always check the ingredients list of foods to ensure they do not contain watermelon.
It is vital to let all your health care providers know about your watermelon allergy. This includes physicians, dietitians, dentists, and even pharmacists. They can advise you on alternative nutrients, adjust your medications accordingly, and provide other essential healthcare considerations.
When dining out or eating food that you did not prepare yourself, always inquire about the ingredients used. Be explicit about your allergy and ask for confirmation that the meal does not contain watermelon or any of its derivatives. It's better to be safe than sorry.
Under doctor's advice, keep over-the-counter antihistamines on hand. These can help in dealing with minor allergic reactions. However, if you have a history of severe reactions, you may need to carry an injectable form of epinephrine with you at all times.
Ready to forget about allergy hassles? Try immunotherapy!

Review your allergy test results with a Curex allergist.

Cross-Reactivity in Watermelon Allergy
Components of Watermelon Allergy
Differences in Reactions
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Treatment prescribed
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Discover key symptoms, diagnosis tips & dietary remedies for watermelon allergy. Learn how to avoid triggers and ease symptoms.







Dr. Chet Tharpe, M.D..
Updated July 9, 2025
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One of the most common symptoms of a watermelon allergy is itching or hives. These appear as red, itchy rashes on the skin, typically around the mouth and lips, but they may also spread to other parts of the body.
Swelling, particularly of the face, lips, tongue, and throat, is another symptom of a watermelon allergy. This can cause discomfort and in severe cases, can interfere with breathing and necessitate immediate medical attention.
Some people may experience stomach cramps or upset stomach after eating watermelon. This is due to the body's immune system responding to the perceived threat posed by certain proteins found in the fruit.
Nasal congestion manifests itself with a stuffy or runny nose. This symptom arises as part of the body's immune response to an allergen, in this case, watermelon.
A severe reaction to watermelon can lead to gastrointestinal issues such as vomiting or diarrhea. This is the body's way of trying to eliminate the allergen from its system quickly.
In the most severe cases, watermelon allergies can lead to anaphylaxis, a severe, potentially life-threatening allergic reaction. Symptoms include difficulty breathing, reduced blood pressure, loss of consciousness, and in some cases, death. Anaphylaxis requires immediate medical attention.
Recognize your symptoms?

Watermelon Growing Season in the U.S.
Watermelons are typically planted in the U.S. during the warmer months when soil temperatures reach around 70°F. The exact time can vary depending on the region. Generally, planting can start in early to mid-spring, which is around March to May. Given that watermelons take about 70 to 90 days to mature after being planted, their peak season tends to be during the heat of summer, around July through September. By late fall, the growth of watermelons typically ends. It's also important to note that watermelons prefer long growing season and warm weather, hence, they do not grow throughout the year.
Note on Allergen:
Watermelons can produce an allergen known as "Cucurbitacin E" which is found in most parts of the fruit. Reactions to this allergen can vary from person to person.



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Don't wait until next season. Start now and enjoy a life free from allergies!
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Review your allergy test results with a Curex allergist.

Treatment prescribed
by clinician


Clinicaly made allergen extracts are customized for your allergies


Your immune system gets desensitized to allergens, giving you long-term relief.
Get started with the most affordable immunotherapy for only $49 $9.99
Discount applied at checkout.


Discover key symptoms, diagnosis tips & dietary remedies for watermelon allergy. Learn how to avoid triggers and ease symptoms.







Dr. Chet Tharpe, M.D..
Updated July 9, 2025

Swelling, particularly of the face, lips, tongue, and throat, is another symptom of a watermelon allergy. This can cause discomfort and in severe cases, can interfere with breathing and necessitate immediate medical attention.

Watermelon Growing Season in the U.S.
Watermelons are typically planted in the U.S. during the warmer months when soil temperatures reach around 70°F. The exact time can vary depending on the region. Generally, planting can start in early to mid-spring, which is around March to May. Given that watermelons take about 70 to 90 days to mature after being planted, their peak season tends to be during the heat of summer, around July through September. By late fall, the growth of watermelons typically ends. It's also important to note that watermelons prefer long growing season and warm weather, hence, they do not grow throughout the year.
Note on Allergen:
Watermelons can produce an allergen known as "Cucurbitacin E" which is found in most parts of the fruit. Reactions to this allergen can vary from person to person.

One of the most common symptoms of a watermelon allergy is itching or hives. These appear as red, itchy rashes on the skin, typically around the mouth and lips, but they may also spread to other parts of the body.



Don't wait until next season. Start now and enjoy a life free from allergies!
Am I eligible?



Review your allergy test results with a Curex allergist.

Treatment prescribed
by clinician


Clinicaly made allergen extracts are customized for your allergies


Your immune system gets desensitized to allergens, giving you long-term relief.

Watermelon Growing Season in the U.S.
Watermelons are typically planted in the U.S. during the warmer months when soil temperatures reach around 70°F. The exact time can vary depending on the region. Generally, planting can start in early to mid-spring, which is around March to May. Given that watermelons take about 70 to 90 days to mature after being planted, their peak season tends to be during the heat of summer, around July through September. By late fall, the growth of watermelons typically ends. It's also important to note that watermelons prefer long growing season and warm weather, hence, they do not grow throughout the year.
Note on Allergen:
Watermelons can produce an allergen known as "Cucurbitacin E" which is found in most parts of the fruit. Reactions to this allergen can vary from person to person.

It’s a physician-prescribed, custom-compounded formula designed to target all your nasal symptoms at once — congestion, runny nose, post-nasal drip, sneezing, and more.

Formulated by doctors and pharmacologists and backed by clinical research, Quickie combines five powerful ingredients into one easy spray.

Typical prescription may include the following ingredients: Azelastine HCL 0.15%, Mometasone Furoate 0.05%, Oxymetazoline HCL 0.0125%, Ipratroprium 0.06%, Sodium Hyaluronate 0.04%.
Straight to the source. That’s Curex


Quickie is a compounded prescription medication, prepared by a licensed pharmacy. It is not reviewed or approved by the FDA. It is prepared based on your provider’s evaluation of your symptoms and needs. Individual results may vary.

Lauren S.
No longer having to go the doctor's office a few times a week for painful shots.
Tony P.
I have done allergy shots in the past but found it pretty inconvenient to go every week. I really like the ease as compared with physically going to the doctors office.

Robert S.
The treatment is much less expensive than a course of allergy shots at a doctor's office and eliminates numerous trips to the doctor's and all the waiting time.
Janie L.
My seasonal allergies were much less severe than years prior. Most importantly, the convenience of taking drops in my own home is unbeatable.

Most patients feel relief within 15 minutes. We have both short-term relief ingredients as well as longer-term relief to keep you feeling better, longer. Some say it’s like turning off their allergies.
Sneezing runny nose, nasal congestion, post-nasal drip, sinus pressure, itchy nose. Great for outdoor allergies, indoor dust, or when pollen spikes unexpectedly.
No, this formula uses a microdose of oxymetazoline, balanced with anti-inflammatory and moisturizing ingredients to reduce the risk of rebound congestion. Clinical studies over the last decade show that when oxymetazoline is combined with a corticosteroid, it can be used safely over the long term without causing rebound symptoms.
Quickie Spray combines up to five prescription-strength ingredients into a single, personalized formula — targeting multiple symptoms like congestion, post-nasal drip, and inflammation. OTC sprays typically address just one symptom and lack the synergy of a customized blend.
Some ingredients like azelastine may cause a slight taste, but many patients find it milder than traditional OTC sprays. Proper spray technique (head forward, not tilted back) helps minimize drip.We also offer an alternative formulation with olopatadine, which has a gentler taste profile and may be preferred by taste-sensitive patients.
Quickie is designed to replace most other allergy medications. But it is designed to compliment allergy immunotherapy for long-term relief. If you’re currently taking other antihistamines or nasal sprays, tell your Curex provider, so we can adjust your formula to avoid overlap or interactions.
No, Quickie is a personalized compounded prescription prepared by licensed U.S. pharmacies based on your doctor’s evaluation. Compounded medications are not FDA-approved as commercial products, but they are regulated under federal and state pharmacy laws.
Possible side effects include nasal dryness, mild irritation, or occasional nosebleeds. These are typically mild and manageable. Let your Curex provider know about any bothersome or serious effects, so we can fine-tune your prescription if needed.
Quickie is safe for daily use, especially during the first 3–6 months of allergy immunotherapy, when symptoms are still active. Your Curex provider may adjust your dose or frequency as your immune system builds tolerance.
Quickie is designed to be non-sedating, so you can use it before work, school, or exercise without feeling groggy or foggy. In rare cases where drowsiness is reported, let your Curex provider know—we can easily adjust the formula to better suit your needs.
Yes, Quickie Spray can be prescribed for children aged 6 and up, based on your provider’s clinical evaluation.
Follow the instructions from your Curex provider.Most patients are advised to use one spray per nostril, twice daily — morning and evening — for consistent relief.