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Benralizumab (Fasenra) Overview: Benefits, Side Effects | Curex

Explore the latest in allergy relief with our review of Benralizumab (Fasenra). We cover its effectiveness, side effects, and how it compares to other treatments. Perfect for those seeking a comprehensive overview in a concise format.
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Benralizumab (Fasenra) Overview: Category & Primary Use

 

Benralizumab, marketed under the brand name Fasenra, is a monoclonal antibody medication primarily utilized in the management of severe asthma. This drug belongs to the category of biologics, which are treatments derived from living organisms or their cells.

 

Drug Category

 

  • Biologics: A class of drugs that involves using biological processes in their production or have biological components. These medications are often used in treating various chronic conditions that have an immune system component.

 

Uses of Benralizumab

 

  • Severe Asthma: It is specifically prescribed for patients with severe asthma who have a higher eosinophil count, as this particular type of immune cell plays a significant role in the inflammatory process associated with asthma.

 

Conditions Treated by Benralizumab

 

  • Severe Eosinophilic Asthma: Fasenra targets and reduces eosinophils, thereby controlling inflammation and reducing asthma symptoms, such as coughing, wheezing, and difficulty breathing, in patients with eosinophilic asthma.

 

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What Conditions Does Benralizumab (Fasenra) Treat?

 

Benralizumab, marketed as Fasenra, is specifically designed to treat conditions associated with severe eosinophilic asthma. This medication functions by targeting and reducing eosinophils, a type of white blood cell that plays a significant role in inflammatory and allergic responses in the airways.

 

Conditions Treated by Benralizumab (Fasenra)

 

  • Severe Eosinophilic Asthma: Benralizumab is primarily prescribed for the treatment of severe eosinophilic asthma. This subtype of asthma is characterized by high levels of eosinophils in the airways, leading to inflammation, frequent asthma attacks, and difficulty controlling symptoms with standard asthma treatments.
  • Aspiration for Improved Quality of Life: Patients with severe eosinophilic asthma often struggle with reduced lung function and decreased quality of life. By targeting eosinophils, Benralizumab helps to significantly reduce asthma symptoms and attacks, thereby improving overall well-being and daily functioning.
  • Reduction in OCS Dependency: For those patients who are dependent on oral corticosteroids (OCS) to manage severe asthma symptoms, Benralizumab offers an option to reduce or eliminate the need for these medications. This can lead to fewer side effects associated with chronic steroid use.

 

The targeted action of Benralizumab makes it beneficial in specific scenarios of asthma management, particularly where traditional treatments do not suffice in achieving desired control over symptoms.

 

Find out if immunotherapy is right for you

Benralizumab (Fasenra): Effectiveness and Advantages Overview

 

Benralizumab (Fasenra) is a monoclonal antibody used in the management of severe eosinophilic asthma, providing a targeted approach to therapy that can offer several potential benefits.

 

Reduces Asthma Exacerbations

 

  • Eosinophil depletion through benralizumab can lead to fewer asthma attacks.
  • Clinical trials show a reduction in severe asthma exacerbations for patients receiving Fasenra.

 

Improves Lung Function

 

  • Benralizumab enhances forced expiratory volume (FEV1), a key marker of lung function.
  • Patients report improved breathing capacity and control over asthma symptoms.

 

Decreases Steroid Dependency 

 

  • Patients often experience a reduction in the need for oral corticosteroids.
  • Minimizing steroid use helps to avoid long-term side effects related to steroid therapy.

 

Convenient Administration

 

  • Administered once every 8 weeks after initial doses, making it low-maintenance.
  • Patients benefit from fewer clinic visits compared to other treatments.

 

Improved Quality of Life

 

  • Significant improvement in asthma-related quality of life scores is often reported.
  • Greater participation in daily activities without asthma-related interruptions is possible.

 

Targeted Therapy

 

  • Works specifically for patients with elevated eosinophil levels, ensuring tailored treatment.
  • The precision targeting minimizes unnecessary suppression of the immune system.

 

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Dr. Neeta Ogden, MD

Curex is poised to revolutionize the way allergies are treated in America, expanding access to clinical care and treatments that can meaningfully improve patients quality of life.

Dr. Ravi Patel, VP Telemedicine

At Curex, our mission is to help people improve their health and quality of life by understanding their allergies and treating them at their source.We provide more than individualized prescription treatments; we provide individualized care.

Jill Hamburg, PA - C

Immunotherapy made simple.  We enable patients to receive personalized allergy care on their own time. No more waiting rooms.

Dr. Chet Tharpe, Medical Director

Curex has set the standard for the virtual allergy experience. From the comfort of their home, patients nationwide are able to receive a personalized treatment plan from an experienced clinician, aimed at treating the source of their allergies, not just the symptoms.

Kayla Mardaga, NP

Curex offers convenient at-home allergy testing options. Our goal is to determine if a patient would benefit from immunotherapy and then customize a treatment plan that can reduce both the symptoms and the reliance on allergy medications.

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Benralizumab (Fasenra) Side Effects: Common and Serious, When to Seek Help

 

Side Effects of Benralizumab (Fasenra)

 

  • Headache: Some patients experience mild to moderate headaches following the injection.
  • Fever: An increase in body temperature is a common side effect.
  • Sore Throat: Irritation or pain in the throat may occur.
  • Injection Site Reactions: Redness, swelling, or pain at the injection site can occur.
  • Fatigue: Feeling unusually tired or weak has been reported.
  • Back Pain: Some individuals may experience discomfort in the lower back.
  • Increased Risk of Infections: There may be a heightened susceptibility to infections due to the suppression of immune functions.

 

Safety Precautions When Using Benralizumab (Fasenra)

 

  • Allergy and Hypersensitivity: Monitor for allergic reactions and hypersensitivity. Seek immediate medical attention if symptoms like swelling, rash, or difficulty breathing occur.
  • Pre-existing Conditions: Inform your healthcare provider about any previous medical conditions, especially immune system disorders or infections.
  • Vaccinations: Discuss any planned vaccinations with your healthcare provider, as live vaccines may not be advisable during treatment with Benralizumab.
  • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as safety in these conditions has not been fully established.
  • Current Medications: Share information about all medications you are currently taking to avoid potential drug interactions.
  • Monitoring: Regular follow-up appointments are important to monitor the response to treatment and any adverse effects.

 

A safer solution to allergies: try immunotherapy today!

Advantages of Immunotherapy over Benralizumab (Fasenra)

 

For individuals managing allergies, immunotherapy can offer a promising alternative to Benralizumab (Fasenra) due to several key benefits and mechanisms of action.

 

Long-term Benefits

 

  • Potential for Lasting Relief: Unlike Benralizumab, which primarily manages symptoms, immunotherapy can offer the possibility of long-term desensitization to allergens, potentially reducing symptoms over time.
  • Modification of Immune Response: Immunotherapy works by gradually reprogramming the immune system to reduce sensitivity to specific allergens, aiming for a more permanent solution.

 

Broader Application

 

  • Multiple Allergen Targets: Immunotherapy is not limited to a single allergen; it can be tailored to address multiple allergens simultaneously, which Benralizumab does not provide.

 

Underlying Allergy Management

 

  • Addressing the Root Cause: By tackling the underlying cause of the allergic reaction, immunotherapy offers a proactive rather than reactive treatment method.
  • Reduces Inflammatory Response: Immunotherapy helps in reducing the overall allergic inflammatory response instead of just suppressing eosinophils like Benralizumab.

 

Economic and Practical Considerations

 

  • Cost-Effectiveness: Although initially more expensive or time-consuming, the long-term reduction in medication and healthcare visits can make immunotherapy more cost-effective than continued use of biologics like Benralizumab.
  • Convenience of Administration: Immunotherapy can be self-administered at home (especially sublingual options), avoiding repeated clinical visits required for injections of Benralizumab.

 

Few Potential Side Effects

 

  • Minimized Risk of Severe Reactions: With carefully monitored dosing, immunotherapy typically leads to fewer systemic side effects compared to biologics.

 

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Benefits of Curex

At-home treatment

Apply treatments in minutes from the comfort of your own home with under-the-tongue applications instead of shots or pills

5-30x higher cumulative dose vs allergy shots

Sublingual immunotherapy delivers a higher dose of allergens over the course of treatment.

Potential for results in as few as 6 months

Individual results vary but some users have reported a noticeable difference in as few as 6-12 months since starting treatments

Excellent safety profile

Studies that have been reviewed by certified physicians show that sublingual immunotherapy is a safe treatment option
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Clinicaly made allergen extracts are customized for your allergies

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Your immune system gets desensitized to allergens, giving you long-term relief.

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