What’s inside
View ResearchDelve into the groundbreaking discovery of a germinal center checkpoint of AIRE in B cells that limits antibody diversification. This study reveals how AIRE, essential for T cell tolerance, interacts with AID to regulate antibody affinity maturation and class switching. The findings highlight AIRE's crucial role in preventing autoimmunity and its potential for generating high-affinity antibodies for immunotherapy.
AIRE's Role in Limiting Antibody Diversification
Exploring how AIRE in B cells controls antibody diversification to prevent autoimmunity and cancer.
AIRE and B Cell Affinity Maturation
Analysis of AIRE's impact on affinity maturation and class switching in germinal center B cells.
Mechanisms of AIRE-Mediated Antibody Regulation
Insights into AIRE's interaction with AID and its inhibition of peripheral antibody diversification.
AIRE Deficiency and Autoimmunity
Investigating the consequences of AIRE deficiency in B cells, leading to altered antibody repertoires and increased autoantibodies.
AIRE's Role in Germinal Center B Cells
Detailed examination of AIRE expression in germinal center B cells and its regulation by CD40 signaling.
AIRE and Immunodeficiency in APS-1
Study of AIRE's involvement in APS-1, highlighting its dual role in autoimmunity and immunodeficiency.
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