What’s inside
View ResearchExplore the creation of a detailed immunoediting map of human cancers through single-cell deconvolution. This study contrasts tumor samples with healthy tissues, identifying significant changes in immune cell types across cancers. Key findings include the increase of mast cells and decrease of NK cells in tumors, offering insights for developing new cancer immunotherapies.
Comprehensive Cancer Immunoediting Map
Study constructs detailed immunoediting map of 33 cancer types using single-cell deconvolution.
Immune Cell Changes in Tumor Microenvironments
Analyzing immune cell perturbations in 11,057 tumor samples from TCGA.
Mast Cell Expansion Across Tumor Types
Mast cells significantly increase in most cancer types, suggesting new immunotherapy targets.
NK Cell Depletion in Human Cancers
Study finds NK cells are depleted in a wide range of human cancers, highlighting immunotherapy potential.
Immune Heterogeneity Between Tumors and Normal Tissues
Revealing higher immune heterogeneity in tumors compared to corresponding healthy tissues.
Sex and Age Impact on Immune Cell Perturbations
Research shows how sex and age influence immune cell changes across different cancer types.
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