Allergy Immunotherapy Researches

Antibody Landscape: C57BL/6 Mice Cured of B78 Melanoma by Immunotherapy

Discover the antibody landscape in C57BL/6 mice cured of B78 melanoma via immunotherapy. Our study uses whole-proteome peptide arrays to reveal a diverse antibody repertoire, highlighting immune memory's specificity and potential to boost cancer immunotherapy effectiveness. Read more.

Written and prepared by:

A Hoefges, SJ McIlwain, AK Erbe, N Mathers, A Xu, D Melby, K Tetreault, T Le, K Kim, RS Pinapati, B Garcia, J Patel, M Heck, AS Feils, N Tsarovsky, JA Hank, ZS Morris, IM Ong, PM Sondel

What’s inside

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Explore the antibody landscape in C57BL/6 mice cured of B78 melanoma via immunotherapy. Utilizing a whole-proteome peptide array, this study identifies a broad repertoire of antibodies targeting linear peptide sequences in melanoma. The research demonstrates the immune memory's specificity and potential for enhancing immunotherapy effectiveness against cancer.

Antibody Landscape in Melanoma Immunotherapy

Comprehensive analysis of antibody responses in C57BL/6 mice cured of B78 melanoma through combined immunotherapy.

Whole-Proteome Peptide Array in Cancer Research

Using high-density peptide arrays to identify antibody targets in mice cured of melanoma via immunotherapy.

Tumor-Specific Antibodies in Melanoma

Study reveals a repertoire of antibodies against melanoma in mice following curative immunotherapy treatment.

Validating Antibody Responses in Melanoma

Cross-validation of antibody binding sites using high-density peptide arrays, JPT multi-well arrays, and ELISA.

Identifying Tumor Antigens in Immunotherapy

Research identifies key tumor antigens recognized by antibodies in melanoma-cured mice.

Reliability of High-Density Peptide Arrays

Study confirms reliability of high-density peptide arrays in detecting antibody responses in melanoma immunotherapy.

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