Allergy Immunotherapy Researches

Basophil & B-Cell Biomarkers: Key in Food Allergy & Immunotherapy Tracking

Discover how Basophil and B-cell biomarkers, like CD63, CD203c, and CD73, are crucial for tracking disease activity in food allergies and oral immunotherapy. This study underscores their potential in monitoring and managing peanut allergy desensitization and long-term tolerance.

Written and prepared by:

Theodore Kim, Richard L. Wasserman, Oral Alpan, Atul Shah, Douglas Jones

What’s inside

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Explore the clinical utility of Basophil and B-cell biomarkers in monitoring disease activity for food allergies and oral immunotherapy. This study highlights the significance of CD63 and CD203c expression on basophils and CD73 expression on B cells in patients undergoing peanut oral immunotherapy (OIT). The research demonstrates that these biomarkers can potentially indicate desensitization and long-term immunological tolerance, aiding in better management and monitoring of peanut allergies.

Basophil Biomarkers in Food Allergy Monitoring

Assessing basophil biomarkers' clinical utility for monitoring disease activity in food allergy patients undergoing oral immunotherapy.

B-Cell Biomarkers in Food Allergy Treatment

Evaluating B-cell biomarkers to track immune changes in food allergy and oral immunotherapy patients.

Peanut Allergy and Oral Immunotherapy

Investigating the effects of peanut oral immunotherapy on basophil activation and immune response.

CD63 and CD203c as Indicators of Desensitization

Study shows decreased CD63/CD203c ratio in basophils of patients undergoing peanut oral immunotherapy.

CD73 Expression in Peanut Allergy Patients

Analysis reveals significant changes in CD73 expression on B cells in peanut allergy and immunotherapy patients.

Immune Monitoring During Peanut Immunotherapy

Highlighting the importance of immune monitoring in peanut oral immunotherapy to predict treatment success and manage complications.

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