What’s inside
View ResearchExplore the discovery and characterization of dietary antigens that induce oral tolerance. This study identifies specific T cell receptors (TCRs) in mice that respond to maize, wheat, and soy proteins, crucial for developing regulatory T cells (Tregs) in the intestine. The research highlights the immunodominant epitopes from these proteins and their role in maintaining immune tolerance, shedding light on mechanisms that could inform allergy prevention and treatment strategies.
Discovery of Dietary Antigens in Oral Tolerance
Study identifies maize, wheat, and soy epitopes recognized by Tregs, revealing their role in immune tolerance.
Maize-Specific Tregs in Immune Tolerance
Maize-derived alpha-zein epitopes predominantly induce Tregs in the intestine, contributing to oral tolerance.
Mechanisms of Immune Tolerance to Food Antigens
Analysis of seed storage proteins reveals their role in promoting immune tolerance through Tregs.
Epitope Conservation Across Plant Kingdom
Study finds cross-reactivity of soy epitopes in various plants, suggesting common immune tolerance mechanisms.
Development of Food-Responsive Tregs in Infants
Introduction to solid foods triggers development of food-responsive Tregs, essential for long-term tolerance.
Transcriptional Profile of Food-Responsive Tregs
Food-responsive Tregs display unique immunosuppressive markers, indicating their role in maintaining tolerance.
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