What’s inside
View ResearchDiscover how peanut oral immunotherapy (OIT) differentially suppresses clonally distinct subsets of T helper cells. This study uses single-cell RNA sequencing and TCR sequencing to analyze peanut-reactive T cells from patients undergoing OIT. The findings reveal specific T cell subsets, such as Th2A-like, Th1, and Th17 cells, and highlight the suppression of Th2 and Th1 signatures during OIT, providing insights into the immunological mechanisms influencing clinical outcomes.
Suppressing T Helper Cell Subsets in Peanut Allergy
Study examines how peanut oral immunotherapy differentially suppresses distinct subsets of T helper cells.
Single-Cell RNA Sequencing in Immunotherapy
Using single-cell RNA sequencing to track T helper cell responses in peanut oral immunotherapy.
Clonal Diversity of T Helper Cells in Peanut Allergy
Analysis reveals six clonally distinct T helper cell subsets in peanut-allergic patients undergoing immunotherapy.
Impact of Immunotherapy on T Helper Cell Phenotypes
Study shows OIT induces suppression of Th2 and Th1 gene signatures in peanut-reactive T helper cells.
Predictors of Immunotherapy Success in Peanut Allergy
High baseline activation of Th17 cells linked to poor clinical outcomes in peanut oral immunotherapy.
Mechanisms of Peanut Oral Immunotherapy
Research highlights selective clonal suppression as a key mechanism of peanut oral immunotherapy.
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